receiver operating characteristic curve and odds ratio should be used with caution
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Receiver Operating Characteristic Curve and Odds Ratio Should Be Used with Caution
We read with interest the article by Abu El Makarem MA et al. (1) entitled, “Platelet count/bipolar spleen diameter ratio for the prediction of esophageal varices: The special Egyptian situation.” This study evaluated noninvasive predictors of esophageal varices in cirrhotic patients by multivariate logistic regression and receiver operating characteristic (ROC) curve analysis. However, in our ...
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Liposome-mediated RNA transfection appears to present a number of advantages for studying the metabolism of reporter mRNAs in mammalian cells. This method is also widely used to transfect siRNAs. Here we describe results indicating that reporter mRNAs introduced into HeLa cells by liposomes do not present the expected behaviors. Namely, the stability of reporter mRNAs was independent of the pre...
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Transient transfection of chemically synthesized microRNA (miRNA) mimics is being used extensively to study the functions and mechanisms of endogenous miRNAs. However, it remains unclear whether transfected miRNAs behave similarly to endogenous miRNAs. Here we show that transient transfection of miRNA mimics into HeLa cells by a commonly used method led to the accumulation of high molecular wei...
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This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies...
متن کاملAdvantages to transforming the receiver operating characteristic (ROC) curve into likelihood ratio co-ordinates.
Traditionally, the receiver operating characteristic (ROC) curve for a diagnostic test plots true positives (sensitivity) against false positives (one minus specificity). However, this representation brings with it several drawbacks. A transformation to positive and negative likelihood ratio co-ordinates, scaled by base-ten logarithms, offers several advantages. First we motivate the use of pos...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۱، شماره ۹، صفحات ۷۵۷-۷۵۷
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